#Edem papile skin#

An alternative is Nukleinsaureamplifikationsmethoden (eg PCR) is particularly suitable is the investigation of joint aspirates or synovial, since there obviously can not be cultured Borrelia survive even after therapy.

#Edem papile skin#

The cultivation of the pathogen (CSF, skin biopsy) is possible but time-consuming and subject to special laboratories. As an ELISA screening test is recommended despite lower sensitivity of immunoblot as confirmatory test. It should be noted, however, that a negative serology does not always rule out Lyme disease. In typical manifestations (skin, neurological symptoms, heart, joints) is primarily driven by the differential diagnosis of Lyme disease, which is backed by one antibody detection (serum, CSF or serum-CSF pairs to determine the indigenous production of specific antibodies in CSF). Hotly debated the existence of a so-called 'post-Lyme syndrome' is. Involvement of the eyes in all three stages in the form of uveitis or optic neuritis described. Antibodies are detectable at 90 to 100% of those affected, usually only IgG. In rare cases, the infection manifests as a chronic encephalomyelitis with para-and tetra paresis. Lyme arthritis is a relapsing or chronic mono-or oligoarticular disease, are affected ankles, elbows, fingers, toes and wrist joints as well as TMJ. Stage III (months to years): Acrodermatitis chronica atrophicans (ACA) Herxheimer with atrophy of the skin ('cigarette paper-thin'), antibodies are not detectable in all patients. Antibodies are detectable at 70 to 90% of patients. Manifestations may occur as the heart myocardium, and peri-carditis, atrioventricular conduction disturbances are possible up to a complete block and ST-T changes, atrial fibrillation, ventricular extrasystoles, tachycardia, impaired ventricular function through to heart failure. On the skin it comes in rare cases as a manifestation of Borrelia Lymphozytom (Lymphocytoma cutis benigna other types) in the form of a livid reddish tumor (earlobe, nipple or scrotum). In rare cases, with a participation of the Optic nerve and blindness results. Cranial nerves are affected, mainly consist-or bilateral facial paralysis. Stage II (after weeks and months): Garin Bujadoux-Bannwarth syndrome (lymphocytic meningoradiculitis) with burning radicular pain, asymmetric flaccid paralysis and unsystematically distributed, often combined with sensory deficits, which can last for weeks or months. Early neuroborreliosis with facial palsy, lymphocytic meningitis (mainly as a manifestation of head pain, and photophobia, nausea, vomiting and mortality was 0.6%, mainly in children between 5 and 15 years), encephalitis, radiculitis. Antibodies are detectable at 20 to 50% of patients. Partly uncharacteristic symptoms such as fever, headache (meningism), myalgia, arthralgia, and conjunctivitis Lympknotenschwellungen. with an initial papule, followed by a sharply demarcated, painless, non-itching erythema which spreads centrifugally and fades away in the middle. Stage I (after a few weeks and months): erythema (chronicum) migrans skin. Similar to syphilis, the disease course in three will be divided overlapping stages, with a remission is possible in each of the stages. The name derives from the Lyme disease Lyme, Connecticut (USA). After penetrating into the bloodstream pathogens show a tropism, are primarily affected skin, myocardium, synovial fluid and nerve tissue. The transmission of the pathogen occurs in the late act of sucking for 24 to 48h. Transmission from human to human is not known, not even during pregnancy or through breast milk. In the eastern states, including Berlin, the number of reported infections has risen to 2006 with 6241 infections in the ensuing years has declined moderately. After contact with infected ticks, a seroconversion developed in 20 to 30% of cases. About 1.5 to 6% of people with tick bites show a seroconversion (infection), at 0.3 to 1.4% is expected to overt disease. The period of tick activity is dependent on the weather from about March to October. Adult ticks are about 20% infected nymphs and larvae of 10 to 20% to about 1%. Pathogen reservoirs are small rodents, birds and deer. The transmission of pathogens carried by a tick bite (Ixodes ricinus, Ixodes vulgo). Lyme disease occur in the northern hemisphere and are widely used in all German regions. Presumably, the transition takes place in round body for spirochetal survival in the tissue has a significant role. These are gram-negative spiral bacteria, a culture of bacteria is possible in special media. burgdorferi sensu stricto (ss), B.garinii, and B.afzelii B.spielmanii. According to current knowledge, four species are pathogenic to humans: B. burgdorferi sl (a total of 12 species) belongs to the genus Borrelia, family Spirochaetaceae.